There is evidence that the evolutionary divergence of HLA class I genotype impacts the efficacy of cancer immunotherapy.
Read more about HLA class-I allele divergence in
Molecular Biology And Evolution
If you use this tool, please cite the following two papers.
Chowell, D., Krishna, C., Pierini, F., Makarov, V., Rizvi, N. A., Kuo, F., … Chan, T. A. (2019). Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy. Nature Medicine, 25(11), 1715–1720.
Pierini, F., & Lenz, T. L. (2018). Divergent Allele Advantage at Human MHC Genes: Signatures of Past and Ongoing Selection. Molecular Biology and Evolution, 35(9), 2145–2158. Retrieved from
Select any two HLA class I alleles to calculate the evolutionary divergence between them.
Loci A, B, C & Mean
Select HLA class I alleles for loci A, B, and C to calculate the evolutionary divergence between at each locus as well as the mean evolutionary divergence.