There is evidence that the evolutionary divergence of HLA class I genotype impacts the efficacy of cancer immunotherapy.
Read more about HLA class-I allele divergence in Nature Medicine and in Molecular Biology And Evolution .
If you use this tool, please cite the following two papers.
Chowell, D., Krishna, C., Pierini, F., Makarov, V., Rizvi, N. A., Kuo, F., … Chan, T. A. (2019). Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy. Nature Medicine, 25(11), 1715–1720. https://doi.org/10.1038/s41591-019-0639-4
Pierini, F., & Lenz, T. L. (2018). Divergent Allele Advantage at Human MHC Genes: Signatures of Past and Ongoing Selection. Molecular Biology and Evolution, 35(9), 2145–2158. Retrieved from http://dx.doi.org/10.1093/molbev/msy116
Select any two HLA class I alleles to calculate the evolutionary divergence between them.
The HED between and is .
Loci A, B, C & Mean
Select HLA class I alleles for loci A, B, and C to calculate the evolutionary divergence between at each locus as well as the mean evolutionary divergence.